Despite all the hype, however, the match will do well to live up to some of the Manchester derby tussles down the years. Here are five of the most memorable:
Real Madrid's stuttering season continued as they were reduced to 10 men and then slumped to an 11th La Liga defeat of the campaign by going down 3-1 at Real Sociedad.
Atletico Madrid's Brazil-born forward Diego Costa has signed a formal letter stating his wish to play for adopted country Spain, ending a tug-of-war between the two powerhouses over the in-form 25-year-old.
Defending champion Germany suffered a shocking defeat, while Brazil, Spain and Argentina -- the other pre-tournament favourites -- managed just draws in their opening round matches.
Barca overcome solid Bilbao challenge to scrape through 1-0.
It was a dramatic night at the Champions League as Barcelona's Anssumane Fati -- 17 years and 40 days old - became the youngest to net a goal in the competition. Last season's semi-finalists, Ajax were eliminated by Valencia while Napoli's coach Ancelotti was shown the door despite the team's progress. Here are Images from the Champions League matches played on Tuesday
Rafael Nadal easily avoided the embarrassment of a back-to-back first round exits at the Australian Open on Tuesday, ramping up his serve and rattling off 39 winners to beat Florian Mayer 6-3, 6-4, 6-1 on Rod Laver Arena.
Antoine Griezmann and Yannick Carrasco each conjured moments of magic as Atletico Madrid recaptured top spot in La Liga from Barcelona with a hard-fought 2-0 victory at Celta Vigo on Sunday.
First win for Liverpool manager Klopp, City thrash Palace 5-1
There was the usual frenzy of last-minute deals as the English Premier League brought the curtain down on another bumper European transfer window in which Manchester City again flexed their financial muscle as the continent's top spenders.
A summary of sports events and persons who made news on Friday
As Leicester City celebrates its unexpected title triumph, Bikash Mohapatra/Rediff.com lists similar success stories across Europe's top leagues.
.. And other memorable couple outings at Cannes Film Festival.
Two big derbies and an eventful weekend of football awaits us all...
Substitute Costa slipped the ball past the keeper from close range in the 48th minute of the second half to break the deadlock and extend Brazil's winning run to 11 matches.
News of all that's transpired on and off the football field
Having returned to England after his humiliating ouster from Chelsea, it is up to Jose Mourinho to leave a positive legacy at Manchester United.
A round-up of Wednesday's night's UEFA Chmpions League matches.
Images from the Champions League matches played across Europe on Tuesday
Rinki Roy Bhattacharya pays tribute to her aunt Sonali Dasgupta, who eloped with filmmaker Roberto Rossellini in 1956, and then made a life in Europe.
A round-up of the 2018 World Cup qualifiers played on Thursday
Andy Murray clinched the Vienna Open title on Sunday with a 5-7, 6-2, 7-5 victory over David Ferrer, one of the Briton's main rivals in the battle to qualify for the ATP World Tour Finals.
Two goals from Thomas Mueller and one from substitute Mario Goetze helped Bayern Munich kick off their Champions League campaign with an impressive 3-0 victory over Olympiakos.
A summary of Thursday night's UEFA Champions League matches.
European powerhouse France rallied from a goal down to hand a 5-1 drubbing on Honduras and qualify for the knockout stage as group toppers in the FIFA Under-17 World Cup in Guwahati.
A summary of the results of the major European football league matches on the weekend.
Karim Benzema came off the bench to score 13 minutes from time and ruin any chance of a dream result for resilient Ludogorets as holders Real Madrid carved out a patchy 2-1 win in Wednesday's Champions League Group B match.
India's Leander Paes and Rohan Bopanna crashed out of the Japan Open following a straight set defeat against Ivan Dodig and Marcelo Melo, in Tokyo on Thursday.
Switzerland struck twice in quick succession to stun Euro 2016 champions Portugal 2-0 in a World Cup qualifier on Tuesday and hand them a first competitive defeat in two years under coach Fernando Santos.
Photos from the Champions League matches played across Europe on Tuesday.
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